With fat: What's good or bad for the heart, may be the same for the brain

[ Back to EurekAlert! ] Public release date: 18-May-2012
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Contact: Jessica Maki
jmaki3@partners.org
617-534-1603
Brigham and Women's Hospital

A new study from Brigham and Women's Hospital found that certain types of fat were associated with worse memory and overall cognitive function

Boston, MA--It has been known for years that eating too many foods containing "bad" fats, such as saturated fats or trans fats, isn't healthy for your heart. However, according to new research from Brigham and Women's Hospital (BWH), one "bad" fatsaturated fatwas found to be associated with worse overall cognitive function and memory in women over time. By contrast, a "good" fatmono-unsaturated fat was associated with better overall cognitive function and memory.

This study is published online by Annals of Neurology, a journal of the American Neurological Association and Child Neurology Society, on May 18, 2012.

The research team analyzed data from the Women's Health Studyoriginally a cohort of nearly 40,000 women, 45 years and older. The researchers focused on data from a subset of 6,000 women, all over the age of 65. The women participated in three cognitive function tests, which were spaced out every two years for an average testing span of four years. These women filled out very detailed food frequency surveys at the start of the Women's Health Study, prior to the cognitive testing.

"When looking at changes in cognitive function, what we found is that the total amount of fat intake did not really matter, but the type of fat did," explained Olivia Okereke, MD, MS, BWH Department of Psychiatry.

Women who consumed the highest amounts of saturated fat, which can come from animal fats such as red meat and butter, compared to those who consumed the lowest amounts, had worse overall cognition and memory over the four years of testing. Women who ate the most of the monounsaturated fats, which can be found in olive oil, had better patterns of cognitive scores over time.

"Our findings have significant public health implications," said Okereke. "Substituting in the good fat in place of the bad fat is a fairly simple dietary modification that could help prevent decline in memory."

Okereke notes that strategies to prevent cognitive decline in older people are particularly important. Even subtle declines in cognitive functioning can lead to higher risk of developing more serious problems, like dementia and Alzheimer disease.

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This work was supported by research grants and awards from the National Institutes of Health (NIH)/National Heart Lung and Blood Institute (HL043851 and HL080467); NIH/National Cancer Institute (CA047988); and NIH/National Institute on Aging (AG015933 and K08 AG029813).


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 18-May-2012
[ | E-mail | Share Share ]

Contact: Jessica Maki
jmaki3@partners.org
617-534-1603
Brigham and Women's Hospital

A new study from Brigham and Women's Hospital found that certain types of fat were associated with worse memory and overall cognitive function

Boston, MA--It has been known for years that eating too many foods containing "bad" fats, such as saturated fats or trans fats, isn't healthy for your heart. However, according to new research from Brigham and Women's Hospital (BWH), one "bad" fatsaturated fatwas found to be associated with worse overall cognitive function and memory in women over time. By contrast, a "good" fatmono-unsaturated fat was associated with better overall cognitive function and memory.

This study is published online by Annals of Neurology, a journal of the American Neurological Association and Child Neurology Society, on May 18, 2012.

The research team analyzed data from the Women's Health Studyoriginally a cohort of nearly 40,000 women, 45 years and older. The researchers focused on data from a subset of 6,000 women, all over the age of 65. The women participated in three cognitive function tests, which were spaced out every two years for an average testing span of four years. These women filled out very detailed food frequency surveys at the start of the Women's Health Study, prior to the cognitive testing.

"When looking at changes in cognitive function, what we found is that the total amount of fat intake did not really matter, but the type of fat did," explained Olivia Okereke, MD, MS, BWH Department of Psychiatry.

Women who consumed the highest amounts of saturated fat, which can come from animal fats such as red meat and butter, compared to those who consumed the lowest amounts, had worse overall cognition and memory over the four years of testing. Women who ate the most of the monounsaturated fats, which can be found in olive oil, had better patterns of cognitive scores over time.

"Our findings have significant public health implications," said Okereke. "Substituting in the good fat in place of the bad fat is a fairly simple dietary modification that could help prevent decline in memory."

Okereke notes that strategies to prevent cognitive decline in older people are particularly important. Even subtle declines in cognitive functioning can lead to higher risk of developing more serious problems, like dementia and Alzheimer disease.

###

This work was supported by research grants and awards from the National Institutes of Health (NIH)/National Heart Lung and Blood Institute (HL043851 and HL080467); NIH/National Cancer Institute (CA047988); and NIH/National Institute on Aging (AG015933 and K08 AG029813).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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Business Consulting: 20 excuses you will hear from your sales team ...

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Whether in a large corporation or a small company, high-tech or low-tech, salespeople, whether newbies or veterans, always know exactly what to say when the quarter doesn?t work for them.

Here are 20 popular responses to a bad quarter. How many of them sound familiar?

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  1. It was clear back then that the annual target is not achievable!
  2. I admit, it?s my fault; I should never have agreed to those crazy targets in the first place
  3. How come the company is committed to 10% annual growth, but I have to deliver 30% growth?
  4. The next quarter will be much better, I hope?
  5. You tell me, do we have a marketing department?
  6. How many times did I ask for my own presale?
  7. I sent you the proposal our competitors sent to my customer, didn?t I?
  8. I asked for an additional discount; now it?s too late?
  9. Customers don?t like to pay cash in advance! You want growth with no risk!
  10. If we could only allow revenue sharing, I would hit my target twice over!
  11. So what if I?m late to work? I meet my targets. Well, usually?
  12. The fact that I was late to the customer?s presentation has nothing to do with our loss!
  13. I have great chemistry with the customer, why would you think I don?t!
  14. Their CEO just left the company and all purchase orders are frozen.
  15. The sales cycle seems to be longer than we all thought
  16. December has only 15 work days.
  17. Sorry, but everyone is gone in July and August?
  18. I hate this laptop; I need a proper laptop!
  19. The demo unit that we sent didn?t work! What do you expect?
  20. I guess it?s not a good time to ask for a raise, is it?

As a business consulting firm, we can help you reduce excuses and increase your delivery. We open the doors and we let your sales team step in and do the job.

We help companies penetrate emerging markets quickly and at the lowest possible cost. Contact us to discuss what we can do for you!

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News Summary: Markets hit new lows on Greece

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Researchers untangle complex genetic processes underlying breast ...

By Eric W. Dolan
Thursday, May 17, 2012 18:13 EDT

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Researchers at the Wellcome Trust Sanger Institute have begun to unravel the complex processes that cause breast cancer, identifying a variety of genetic mutations that emerge during tumor growth.

Their research found that a variety of naturally-occurring mutations in the DNA cells can initiate different sequences of mutations that eventually lead to breast cancer.

?What emerges is a really complex landscape of mutation, where each cancer seems to have been generated by a different combination of mutation processes,? said Professor Mike Stratton, author and Director of the Wellcome Trust Sanger Institute.

The researchers cataloged of all the mutations in the genomes of 21 breast cancers, discovering almost 200,000 different mutations. The different mutations were associated with different periods in the development of a breast tumor, revealing previously unknown patterns of mutation.

?We are used to thinking about Darwinian evolution of species by natural selection taking place over centuries and millennia. But in cancer and infectious disease similar processes can be observed over much shorter periods,? said Sir Mark Walport, Director of the Wellcome Trust. ?These studies, which follow from the human genome project, are untangling the evolutionary processes that eventually lead to breast cancer, in a way that would have been impossible only a few years ago.

?We are starting to see the landscape of mutation that characterizes this disease in something approaching its full complexity for the first time. As this work continues, we can hope to understand how breast cancer develops and thus how it might be treated more effectively.?

Their research was published online on 17 May in Cell.

Mutations slowly accumulate in breast cells over many years, but the researchers found that in 13 of the 21 breast cancer genomes they evaluated there were sporadic bursts of mutations. The researchers named this newly discovered phenomenon kataegis, from the Greek word for thunderstorm.

?In kataegis, a large number of mutations occur very close together in the genome,? says Dr Serena Nik-Zainal, first author from the Wellcome Trust Sanger Institute. ?They show a distinguishing mutational motif and frequently co-occur with large-scale rearrangements: it is a unique mutational pattern.?

[DNA illustration via mathagraphics / Shutterstock]

Eric W. Dolan

Eric W. Dolan has served as an editor for Raw Story since August 2010, and is based out of San Diego, California. He grew up in the suburbs of Chicago and received a Bachelor of Science from Bradley University. Eric is also the publisher and editor of PsyPost. You can follow him on Twitter @ewdolan.

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Google IO sessions schedule listed - Android abounds

Google IO

We've got just a month and a half before Google IO hits San Francisco once more, and Google's just posted the list of sessions for this year's three-day event. As you can imagine there's more than a bit of Android on the agenda, with 20 sessions currently listed. (And it wouldn't surprise us in the least to see one or two more added before June 27 arrives.)

We've yet to find any hidden gems in the session listings -- no "Hey, come check out Jelly Bean" or anything like that -- but there's a whole lot that you coders (and us kibitzers) can look forward to. Hit the link below for the whole thing.

Source: Google IO sessions schedule

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Greek party most extreme of Europe's far right

This combination of six file photos shows from left to right, on the top: Marine Le Pen of France's National Front; Heinz Christian Strache, head of Austria's right-wing Freedom Party or FPOE; Netherlands Freedom Party lawmaker Geert Wilders. And on the bottom from left to right are: Italian Lower Chamber President Gianfranco Fini, former head of the National Alliance and currently head of Italy's Future and Liberty Party; chairman of Hungary's " For A Better Hungary Movement or Jobbik, Gabor Vona; and Pia Kjaersgaard head of the Danish People's Party. (AP Photos)

This combination of six file photos shows from left to right, on the top: Marine Le Pen of France's National Front; Heinz Christian Strache, head of Austria's right-wing Freedom Party or FPOE; Netherlands Freedom Party lawmaker Geert Wilders. And on the bottom from left to right are: Italian Lower Chamber President Gianfranco Fini, former head of the National Alliance and currently head of Italy's Future and Liberty Party; chairman of Hungary's " For A Better Hungary Movement or Jobbik, Gabor Vona; and Pia Kjaersgaard head of the Danish People's Party. (AP Photos)

Members of parliament from the extreme right-wing Golden Dawn party, intermingled with other new lawmakers as they are sworn in during a ceremony at the Greek parliament in Athens, Thursday, May 17, 2012. Among the deputies to take their seats for a day are 21 from the Golden Dawn, which rejects the neo-Nazi label. It campaigned on pledges to rid Greece of immigrants and clean up neighborhoods. (AP Photo/Thanassis Stavrakis)

Twenty-one members of Golden Dawn were sworn into Greece's Parliament on Thursday, making it arguably the most far-right party to enter a European national legislature since Nazi-era Germany. Europe's financial crisis is changing the tone across the continent, with frustrated voters turning to extremists on both the right and left. None seem as extreme as Golden Dawn, whose leaders claim that the Nazis did not use gas chambers to kill death camp inmates during the Holocaust. The party ? which won 7 percent of the vote in a May 6 election ? says it wants to rid Greece of immigrants and plant landmines along the border with Turkey.

The new parliament will hold power just one day because the election left no party with enough votes to form a government, forcing repeat elections next month. Recent polls show falling support for Golden Dawn, so it's not certain to make it into parliament again. Still, many people across Europe are troubled.

"The Golden Dawn party is a dark stain on European politics," said Moshe Kantor, president of the European Jewish Congress. "For the first time in over six decades a seemingly long hidden Nazi ideology returned to power."

Here are other far right parties that have won parliamentary seats and pushed their views into mainstream policies and discourse in Europe, sometimes in ways that have impacted immigrants and Muslims.

FRANCE

France's anti-immigrant National Front was in parliament until 1986, when new rules made it harder for small parties to make it in. Its leaders, first Jean-Marie Le Pen and now his daughter Marine, have featured prominently in presidential elections and maintained a national following. Marine Le Pen came in a strong third place in presidential elections this month, earning more than 6 million votes, and is angling to get National Front candidates back in parliament in legislative elections next month.

While Jean-Marie Le Pen has been convicted and fined a few times for racism and anti-Semitism, Marine Le Pen has sought to soften the party's message, and turned its anger toward what she calls the "Islamization" of France. Those ideas have entered the mainstream discourse, notably in former President Nicolas Sarkozy's push to ban face-covering Islamic veils and keep halal meat out of public cafeterias. He also made reducing immigration a pillar of his presidency.

AUSTRIA

The right-wing Freedom Party consistently polls a close second in popularity to the leading Social Democrats, reflecting the resonance of its anti-immigrant, Euro-skeptic message. It counts the neo-Nazi fringe among its supporters and its leaders' occasional anti-Semitic comments are widely condemned by other parties. Its main draw with voters is Islamophobia. It holds 34, or 1.5 percent of the seats in parliament compared to the nearly 27 percent won in 1999. That result catapulted it into a government coalition ? and led to EU sanctions against Austria. In response to their gains, the federal government has toughened asylum rules and introduced compulsory German courses for immigrants.

NETHERLANDS

The Freedom Party of anti-Islam lawmaker Geert Wilders became the third largest bloc in the Dutch Parliament in 2010 elections with 24 seats. The result turned Wilders into a kingmaker who agreed to support the minority coalition of Prime Minister Mark Rutte on crucial votes in return for concessions such as a crackdown in immigration and a ban on the Islamic veil, the burqa. Wilders, a Euro-skeptic, brought down Rutte's government last month when he refused to support an austerity package aimed at cutting the country's budget deficit to within the EU norm of 3 percent of GDP.

ITALY

The Italian Social Movement, which saw itself as the heir of Benito Mussolini's Fascist party, was Italy's fourth largest party in the decades after the war, gaining up to 6 percent in some cases. But mainstream parties refused any alliance with it so it was kept out of the postwar governing coalitions. It campaigned against immigration and sought tough law enforcement, and some fringe members were linked to right-wing violence. In the early 1990s it morphed into the National Alliance and under party leader Gianfranco Fini moved into the mainstream: It shed its hardline roots, decried anti-Semitism and Mussolini's racial laws, and became a major ally of ex-Premier Silvio Berlusconi. Fini had to pull back from a statement in a newspaper interview that Mussolini was one of the greatest statesmen of the 20th century.

HUNGARY

Hungary's Jobbik party ? The Movement for a Better Hungary ? won nearly 17 percent of the national vote in the 2010 parliamentary elections and is currently the second-largest opposition party in the legislature, behind the Socialists. Jobbik's popularity is highest in Hungary's northeast region, the country's poorest, and some of its support came from its pledge to fight what it calls "Gypsy crime." From 2009, uniformed groups closely tied to Jobbik, such as The Hungarian Guard, set up patrols in countryside villages to "protect" residents from Gypsies, but such activities have been banned under the current, center-right government of Prime Minister Viktor Orban. The Guard and several other such groups use some colors, slogans and symbols of the far-right nationalist parties of the 1930s, and its rhetoric is sometimes anti-Semitic, racist and anti-gay. Racist comments by Jobbik deputies have drawn condemnation from the rest of the parties and Orban's governing Fidesz party's two-thirds majority has allowed it to not make any concessions to Jobbik in the legislature. At the same time, some of the themes Jobbik promotes can also be found to a smaller or larger degree in Orban's policies.

DENMARK

The anti-immigrant Danish People's Party is Denmark's third largest party and has pushed the country to adopt some of Europe's strictest immigration laws, leading to a drastic cut in the number of refugees seeking shelter there to just over 5,000 in 2011, from 13,000 in 2001. Last year, it also pushed through a plan to reinstate custom checks at Denmark's borders with Germany and Sweden. Both the European Union and Germany sharply criticized the move, with the EU accusing Denmark of violating the spirit of EU rules on free movement for goods and people.

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Associated Press writers Elena Becatoros in Athens, Angela Charlton in Paris, George Jahn in Vienna, Victor Simpson in Rome, Mike Corder in Amsterdam, Pablo Gorondi in Budapest and Louise Nordstrom in Stockholm contributed to this report.

Associated Press

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Autopsy: Trayvon Martin shot from 'intermediate range'

George Zimmerman's lawyer has signaled that he may seek a dismissal of the second-degree murder charges against his client under Florida's Stand Your Ground Law. NBC's Michael Isikoff reports.

By NBC News and msnbc.com

Florida teenager Trayvon Martin died from a single gunshot wound to the chest fired from ?intermediate range,? according to an autopsy report reviewed Wednesday by NBC News.

The official report, prepared by the medical examiner in Volusia County, Fla., also found that the 17-year-old Martin had one other fresh injury ? a small abrasion, no more than a quarter-inch ?in size ?? on his left ring finger below the knuckle.


Separately, a medical report on Martin?s alleged killer, 28-year-old George Zimmerman, prepared by his personal physician the day after Martin?s shooting in Sanford, Fla., on Feb. 26, found that the Neighborhood Watch volunteer suffered a likely broken nose, swelling, two black eyes and cuts to the scalp. That report, first reported Tuesday by ABC News, also was reviewed by NBC News.

Both documents are part of a mountain of evidence ? up to 300 pages and 67 CDs of witness statements, surveillance videos and other material-- expected to be made public soon in connection with the second-degree murder case against Zimmerman.

Zimmerman allegedly shot Martin during a confrontation inside the gated community in Sanford where Zimmerman was a neighborhood volunteer and where Martin was visiting his father?s fianc?e.

After first reporting a suspicious person in the neighborhood in a phone call to Sanford police, Zimmerman followed the teenager before a fatal confrontation that remains shrouded in mystery.

Related coverage:

NYT: Police missteps shadow Trayvon Martin case

Physician: Zimmerman had broken nose, black eyes

Key events in the Trayvon Martin case

When police arrived at the scene to find Martin dead on the sidewalk, Zimmerman claimed he shot the teen in self-defense. Zimmerman was treated at the scene for cuts and a bloody nose, then questioned by police for hours before being released without being arrested. Authorities said at the time that they had no evidence challenging Zimmerman's account and that his conduct appeared to be justified under Florida's so-called Stand Your Ground law.

But after questions about possible racial motivation for the slaying ? Martin was black; Zimmerman is a white man of Hispanic heritage ? a special prosecutor took over the case and, on April 11, Zimmerman was charged with second-degree murder. He was released on April 23 on a $150,000 bond and has been out of the public eye since then.

NBC News National Investigative Correspondent Michael Isikoff and msnbc.com's Mike Brunker contributed to this report.

More content from msnbc.com and NBC News:

Follow US News on msnbc.com on Twitter and Facebook

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Video: Street Signs Today: JPMorgan's Meeting & Coal Disaster

CNBC's Brian Sullivan and Amanda Drury break down which major headlines they will discuss in an hour of "Street Signs," including anger at JPMorgan's annual shareholder meeting and a disaster for the coal industry.

Related Links:

Business & financial news headlines from msnbc.com

Top of page

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Link: Why Cal could be the next Team USA coach

News that this summer?s Olympics will likely be the final stop for?Mike Krzyzewski as Team USA?s coach is only a day old, but speculation has already begun for the next national team coach?

Could that man be John Calipari?

Take it for what it?s worth, but Bleacher Report thinks Coach Cal could be a perfect fit as the next Team USA coach. The website posted five pretty good reasons why Calipari is the logical next choice:

  1. John Calipari gets things done
  2. Calipari has a unique team-building skill set
  3. The Olympic players would love Coach Cal?s Dribble Drive Motion Offense
  4. He is a players-first coach
  5. Calipari now has championship skin on the wall

Bleacher Report columnist Doug Brodess goes into detail about each reason, which you can read in entirety here.

Calipari has already agreed to terms to coach the Dominican Republic National Team this year in hopes of taking the country to its first-ever Olympics. Coach Cal guided the Dominicans to their best finish in international play last year.

Calipari?s Dominican team is scheduled to?play the U.S. National Team in an exhibition game on July 12 at the University of Nevada-Las Vegas. Could that be an on-the-job interview for Coach Cal for the future?

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Chan Sung Jung delivers submission win (VIDEO)

Would you like to see highlights from the main event of UFC on Fuel 3 along with discussion from Kenny Florian and Jon Anik about "The Korean Zombie's" next move? You're in luck.

For too long, the featherweight division has been so top-heavy that it was a little boring. Now, with Erik Koch and Jung waiting for Jose Aldo, the 145-lbers are giving fans a reason to watch the division.

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